In pursue of effective treatment for severe COVID-19 many different antiviral medication have been used. Combined HIV treatment lopinavir-ritonavir showed some inhibitory activity against SARS-CoV-1 and therefore was trialled in new coronavirus causing COVID-19.
While the world awaits an efficient vaccine for coronavirus, many therapeutics are currently being investigated in hope to improve clinical outcomes. One of the most promising one is currently remdesivir. Wang et al. published the first randomised placebo-controlled trial of its use in severe COVID-19.