Category: Critical Appraisals

Here are listed all critical appraisals published on the website. All of them have been developed using systematic approach and integrating Critical Appraisal Skills Programme checklists.

Tocilizumab in critical COVID-19

Monoclonal antibodies against interleukin 6 are being investigated and used in COVID-19. These drugs have been found to reduce mortality in critically ill patients with COVID-19 pneumonia. Tocilizumab is a known immunomodulatory drug commonly used in rheumatoid arthritis. Its purpose in covid had been looked at in this trial.

Wells’ score adjusted D-dimer in diagnosis of Pulmonary Embolism

Combination of clinical prediction tool and D-dimer should be used in diagnostic algorithm for most cases of suspected pulmonary embolism. Current practice use cut-off of 500 ng/ml for negative in low probability cases. Pulmonary Embolism Graduated D-Dimer (PEGeD) Study looked at the use of D-dimer adjusted to clinical probability in order to decrease the burden of diagnostic imaging in selected patients.