Timotej Vataha

Tocilizumab in critical COVID-19

Monoclonal antibodies against interleukin 6 are being investigated and used in COVID-19. These drugs have been found to reduce mortality in critically ill patients with COVID-19 pneumonia. Tocilizumab is a known immunomodulatory drug commonly used in rheumatoid arthritis. Its purpose in covid had been looked at in this trial.

Wells’ score adjusted D-dimer in diagnosis of Pulmonary Embolism

Combination of clinical prediction tool and D-dimer should be used in diagnostic algorithm for most cases of suspected pulmonary embolism. Current practice use cut-off of 500 ng/ml for negative in low probability cases. Pulmonary Embolism Graduated D-Dimer (PEGeD) Study looked at the use of D-dimer adjusted to clinical probability in order to decrease the burden of diagnostic imaging in selected patients.